It induces COX-2 activity and regulates the biosynthesis of numerous proinflammatory cytokines (IL-1β, IL-6, TNF-α, INF-gamma) that are fundamental in the pathogenesis of autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, Crohn’s disease), asthma and COPD (chronic obstructive pulmonary disease), but also of cardiovascular disorders such as atherosclerosis [120,121,122]. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.