It induces COX-2 activity and regulates the biosynthesis of numerous proinflammatory cytokines (IL-1β, IL-6, TNF-α, INF-gamma) that are fundamental in the pathogenesis of autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, Crohn’s disease), asthma and COPD (chronic obstructive pulmonary disease), but also of cardiovascular disorders such as atherosclerosis [120,121,122]. This evidence concerns the gene PTGS2 and chronic obstructive pulmonary disease.