TNS4 and cancer: Downregulation of E-cadherin, despite being linked to a shift of E-cadherin to N-cadherin during the EMT process [45], has been highly associated with upregulation of CTEN in human cancers, CTEN being considered a mediator in integrin–cadherin crosstalk, promoting E-cadherin inhibition through its degradation or post-transcriptional repression [22,46].