Induced EMT is described in many human cancers, and during this process epithelial cells change their polarity, reorganize cytoskeletal systems, and lose their cell-to-cell adhesion, involving changes in the pattern of expression of some proteins (e.g., E-cadherin and N-cadherin), conferring motility (both invasion and migration) to tumor cells [44]. The gene discussed is CDH2; the disease is neoplasm.