Cell migration and invasion have been proven to be important roles of CTEN, involving several proteins and signaling pathways, including KRAS/BRAF, Src/ROCK/SNAIL, ILK, and FAK in colorectal and pancreatic cancer [12,21,22], and Rho/ROCK/MLC in hepatocellular carcinoma, via DLC-1 [48,49]. Here, RHO is linked to familial pancreatic carcinoma.