Interesting areas for future research may include characterization of local and systemic innate and adaptive cellular subsets associated with severe COVID-19, such as proliferative-exhausted CD8 T cells that may escape detection with functional assays [10,26], or NK cell subpopulations [27], or the quality and quantity of proinflammatory monocyte subpopulations [28], which may also play a role in local protection. The gene discussed is CD8A; the disease is COVID-19.