IFNL3 and hepatitis A virus infection: Specifically, in terms of IFN-lambda, it has been reported that this cytokine, and also the single nucleotide polymorphisms (SNPs) linked to the cytokine IFNλ3 (also known as IL28B), can be involved not only in the spontaneous clearance of Hepatitis C virus (HCV) infections, but also in the higher rates of sustained virological responses associated with combined antiviral therapy [27,28,29].