BTG3 and influenza: First, previous research has demonstrated autoantibody formation following various non-mRNA vaccinations in healthy subjects, such as Toplak et al. [19], who demonstrated the de novo formation or increase in ANA and aPL antibody titers in up to 15% of participants of a cohort of 92 healthy adult subjects post-seasonal influenza vaccination, with 8% showing a persistence of autoantibodies.