Our data showed that in the non-seroconversion group, there were 37.0–58.1% with low lymphocyte count (<1000/mm3), 33.3–45.2% with low CD4 cell counts (<500/mm3), and 74.1–96.8% with low B cell counts (<100/mm3), suggesting that lymphopenia, low CD4 cell counts, and low B cell counts were risk factors for poor or non-responders to vaccines. This evidence concerns the gene CD4 and lymphopenia.