The ability of monocytes and T cells to respond to the stimulation with cell-specific triggers (e.g., LPS, anti-CD3/CD2/CD28) was dampened most significantly in severe COVID-19 of monocytes with LPS, secretion of pro-inflammatory cytokines IL-6, TNFαand IFNFγ (Figure 6c–g) was significantly reduced, while stimulation of T cells with antiCD3/CD2/CD28 resulted in reduced levels of IL-2, IL-6, TNFαand IFNγ (Figure 6h–l). This evidence concerns the gene IFNG and COVID-19.