Furthermore, plasminogen- activator-inhibitor type 1 (PAI-1), a strong inhibitor of fibrinolysis, was upregulated (Figure 8i), while plasminogen and tissue plasmin-activator (tPA) concentrations were unaffected (Figure 8j,k), implying that fibrinolysis was impeded in both groups of COVID-19 patients. The gene discussed is SERPINE1; the disease is COVID-19.