IgG1 and IgG3 were initially associated with severe disease in older adults with COVID-19 (n = 123) disease and accompanying irregularities in neutralizing antibodies (nAbs), chemokines, and T cell responses, which is an anomaly as IgG3 was previously thought to provide enhanced pathogen response [91,119,120]. This evidence concerns the gene IGHG3 and COVID-19.