CXCL10, P2RX7, TLR3, and TLR4 were significantly upregulated in IS2 tumours in the TCGA cohort, whereas ANXA1, CXCL10, FPR1, IFNAR2, P2RX7, and TLR4 showed significantly higher expression levels in IS4 tumours in the GEO cohort. This evidence concerns the gene TLR4 and neoplasm.