CD276, CD44, and VTCN1 were significantly upregulated in IS6 tumours in the TCGA cohort, whereas BTNL2, CD244, CD276, ICOSLG, TMIGD2, TNFRSF18, KIR3DL1, PDCD1, TNFRSF4, TNFRSF8, TNFSF14, TNFSF18, and VTCN1 were overexpressed in IS6 tumours in the GEO cohort. The gene discussed is BTNL2; the disease is neoplasm.