Recently, a self-amplified biomimetic nanosystem, mEHGZ, was prepared by was prepared by encapsulating epirubicin (EPI), glucose oxidase (Gox), and hemin in zeolitic imidazolate framework (ZIF-8) nanoparticles and coating with calreticulin (CRT) over-expressed tumor cell membrane. The gene discussed is CALR; the disease is neoplasm.