The vaccine-induced protection against multiple CVB serotypes in the Balb/c, NOD, and suppressor of cytokine signaling-1 (SOCS-1) transgenic mice models, preventing CVB3-induced myocarditis and pancreatitis with no mortalities, as well as preventing CVB1- and CVB4-induced T1D. This evidence concerns the gene SOCS1 and myocarditis.