Other HAE subtypes with normal C1-INH level (HAEnCI) have been identified, produced by mutations in other genes (i.e., factor 12 (FXII-HAE), plasminogen (PLG-HAE), angiopoietin-1 (ANGPT1-HAE), kininogen-1 (KNG1-HAE), myoferlin (HAE-Myoferlin), and HS3ST6 gene encoding for heparan sulfate glucosamine 3-O-sulfotransferase 6 (3-OST-6)) [6,7,8]. The gene discussed is SERPING1; the disease is hereditary angioedema.