Mean age was 45.3 ± 19 years (range 18–82) for C1-INH-HAE type 1, 57.7 ± 9.1 years (range 51–68) for C1-INH-HAE type 2, 49 ± 14.1 years (range 39–59) for FXII-HAE, and 29 ± 16.8 years (range 16–48) for MYOF-HAE. This evidence concerns the gene SERPING1 and hereditary angioedema.