BDKRB1 and edema: Indeed, the activation of bradykinin receptor 1 (B1R) and bradykinin receptor 2 (B2R) on endothelial cells in the lungs, which causes vascular alterations resulting in a localized kinin-dependent local lung angioedema, has been proposed as part of the pathogenetic mechanism involved in the development of pulmonary edema in COVID-19 [25].