Beyond the genetic traits determined by loci near immune related genes such as IFNAR2 and CXCR6 [124], the distinct genetic variants of highly polymorphic Ace2 (gene located on chromosome Xp22.2 encoding for ACE2 protein [125]) in different populations have also been shown to affect the susceptibility to and severity of COVID-19 in some cohorts of patients [126,127,128,129]. This evidence concerns the gene ACE2 and COVID-19.