Furthermore, numerous lncRNAs, including lncRNA-LET [20], lncRNA-PRAL [21] and lnc-DILC [22] were found to be downregulated in HCC tissues and dramatically inhibited HCC growth by regulating histone acetylation, p53 ubiquitination, or autocrine interleukin-6/STAT3 signaling. The gene discussed is PRAL; the disease is hepatocellular carcinoma.