The restoration of MEG3 expression suppressed tumor growth [43] and induced apoptosis in several human cancer cell lines, including lung cancer A549 cells [44], tongue squamous cell carcinoma cell lines SCC-15 and CAL27 [45], and gastric cancer cell lines SGC7901, AGS, MGC803, MKN45, and BGC823 [37]. Here, MEG3 is linked to tongue squamous cell carcinoma.