Our results revealed that SOR, NSP, or combined NSP /SOR downregulated the inflammatory cytokines with marked improvement in HCC-treated rats with a combined NSP/SOR; these data were in line with [49], where Arthrospira platensis reduced the hepatic expression of TNF-, IL-6, iNOS, and TGF-1. This evidence concerns the gene TNF and hepatocellular carcinoma.