BAX and breast cancer: AM has antiproliferative activity and apoptotic effects on different types of cancer, one of which is breast cancer, among the mechanisms of inducing apoptosis in breast cancer cells through the downregulation of B-cell lymphoma 2 (Bcl2) and the upregulation of Bcl-2-associated X protein (Bax) against breast cancer cells [6,7,8,9,10].