Mechanistic studies suggest that exercise may improve age-related regeneration and cognitive impairment by altering the expression of related proteins in the urokinase-type plasminogen activator receptor (uPAR) signaling pathway downstream of GPI anchored substrate cleavage (41 coagulation and complement proteins in the uPAR signaling pathway were found to be reduced after exercise) [112]. This evidence concerns the gene PLAUR and Cognitive impairment.