As DNA methylation may affect binding of TFs to specific motifs, we evaluated DNA methylation levels within c-Jun motifs and their flanking regions (c-Jun motif +/− 20 bp) in enhancers detected in gliomas with IDH1 wild type (IDHwt) or mutant (IDHmut) status from the Glioma Atlas [4]. Here, JUN is linked to glioma.