Among the genes potentially controlled by c-Jun, we identified two clusters: the first containing genes with high DNA methylation in GII/GIII-IDHmut and GII/GIII-IDHwt gliomas but low in GIV gliomas (RIN1, RAB36, UPP1, SLFN12 and VIM), and the second one encompassing genes with low DNA methylation (beta values ~ 0) regardless of the tumor grade (PTN, FOSL2, FAM111B, SIAH2, SPATA1, TMEM43, TRIB1 and GPR3) (Fig. 6A). The gene discussed is SIAH2; the disease is central nervous system cancer.