To identify TF-gene regulatory networks driving transcriptional deregulation in gliomas, we exploited public TCGA datasets as well as the Glioma Atlas created in our laboratory, which encompasses genome-wide profiles of chromatin accessibility, histone modifications, DNA methylation and gene expression from the same tumor sample [4] (a summary information is presented in Additional file 2: Fig. S1). Here, TF is linked to central nervous system cancer.