Many HOMEOBOX (HOX)-related genes (HOXD11, HOXD9, HOXC10, HOXC11, HOXC6, HOXB3, HOXA2, HOXA1) were associated with a glioma grade and significantly overexpressed in GIV (Wilcoxon rank-sum and BH padj < 0.05). The gene discussed is HOXB3; the disease is central nervous system cancer.