DDR2 is a receptor tyrosine kinase (RTK), and it has been shown to be activated through fibrillar collagens [46] and involved in cell behaviors of different types of cancer, including VEGF expression, differentiation, tumor angiogenesis, invasion, and metastatic potential of HNSCC cell lines [46]. The gene discussed is NTRK1; the disease is head and neck squamous cell carcinoma.