PDGFRB and metastatic malignant neoplasm in the lymph nodes: The binding of PDGF ligands to this receptor leads to dimerization and activation of downstream signaling pathways having a role in the regulation of motility and proliferation, differentiation, and survival of cells [52]. Lin et al., in their study, indicated that PDGFRB expression level was associated with poor prognosis and lymph node metastasis of OSCC [53].