HOTAIR and breast cancer: Generally, BC cells associated lncRNAs can be classified into two groups of enhance or attenuate the aggressiveness of BC cells, for example, DANCR, H19, HOTAIR, LINC00152, LINC00461, NEAT1, and LINC01857 cause invasion and migration of BC cells, H19, HOTAIR, HIF1A-AS2, RP1, and MALAT1 promote distant metastasis of BC cells, GAS5, MT1JP, NEF, NKILA, LET, TFAP2A-AS1, LncKLHDC7B prevent the invasion and migration of BC cells, MALAT1, MEG3, NLIPMT, and XIST inhibit distant metastasis of BC cells [16].