As MALAT1 and TUG1 are associated with migration, invasion, metastasis, progression, EMT, relapse-free survival, proliferation, angiogenesis, motility, apoptosis, tumor growth, and tumor size of BC (Table 1 and Additional file 1: Table S1), metformin can regulate these features by MALAT1 and TUG1 activities. This evidence concerns the gene TUG1 and breast cancer.