Also, obvious c-Myc binding peaks are observed in the promoter region of RCC1 by ChIP-seq (data not shown), c-Myc significantly binds to the promoter of RCC1 in U937 cells, and the combination significantly reduced c-Myc binding in the promoter region of RCC1 compared to the single drug control, and c-Myc knockdown induces RCC1 down-regulation in AML cells, indicating CHI plus CLA downregulated RCC1 expression in a c-MYC-dependent manner. This evidence concerns the gene RCC1 and acute myeloid leukemia.