BRAF and colorectal carcinoma: The multivariate analysis demonstrated that surgical treatment of the primary tumor (P = 0.001; HR, 0.326; 95% CI, 0.169–0.631) and liver metastasis (P = 0.009; HR, 2.399; 95% CI, 1.242–4.635) could potentially be used as independent prognostic indicators of OS in patients with BRAF-mutated advanced CRC (Table 3).