Factors associated with dialysis headaches include sodium ion, magnesium ion [6], urea, blood pressure changes, and weight levels; calcitonin gene-related peptide and substance P levels during dialysis [7]; and different haemodialysis (HD) modalities (standard HD and online hemodiafiltration technique (OL-HDF), standard HD presents a higher risk of dialysis headache than OL-HDF) [8]. Here, TAC1 is linked to Headache.