Among them, studies have proved that CCNB1, RACGAP1 and NUSAP1 promote the progression of multiple cancers (Aljohani et al. 2022; Gu et al. 2022; Guo et al. 2020), and NCAPG and CCNB2 have been found to be associated with a poor prognosis of ES (Kakar et al. 2022; Zhao et al. 2022), while ASPM, CENPF, CKS2, and DTL have not been studied in ES to the best of our knowledge. This evidence concerns the gene ASPM and Ewing sarcoma.