The adjusted means and standard errors for log2 transformed p16INK4a are derived from mixed linear models including all subjects in intent-to-treat analyses, and graphically displayed in the figure for baseline (prior to treatment), following treatment (2 months), and 24 months after treatment initiation for four groups, sleep education treatment (SET) without remission (Blue), SET with sustained remission (red), cognitive behavioral therapy for insomnia (CBT-I) without remission (Black), and CBT-I with sustained insomnia remission (green line). The gene discussed is CDKN2A; the disease is insomnia measurement.