A gene distribution analysis revealed that SMARCD3 is in the top 7.331% of the 1,937 genes that are highly expressed in G3 tumours with metastasis and the top 8.584% of the 3,984 genes that are highly expressed in all MB subgroups with metastasis compared with MB types without metastasis (P < 0.05, log2(fold change) > 0) (Extended Data Fig. 1g). This evidence concerns the gene SMARCD3 and neoplasm.