It was previously reported that PI3K inhibition induces apoptosis by upregulating forkhead box O1/3 (FOXO1/3), transcription factors downstream of PI3K signaling, and thereby transactivate the expression of PUMA or BIM in hepatocellular carcinoma and colorectal cancer, respectively [30, 31]. Here, FOXO1 is linked to hepatocellular carcinoma.