RIPK3 and neoplasm: 2-Hydroxyglutarate (2-HG), a product of mutant isocitrate dehydrogenase 1 (IDH1), binds to DNA methyltransferase 1 (DNMT1) and induces the hypermethylation of the RIPK3 promoter, thereby rendering tumor cells more resistant to necroptosis [141].