The fact that GMDS-AS1 was induced by both IL-6 (Figs. 1A and 3G) and Wnt-3a (Fig. S5H, I) means that there is one GMDS-AS1/HuR-mediated positive feedback to maintain persistent activation of STAT3 and Wnt signaling, and the GMDS-AS1-HuR-STAT3/Wnt axis connects the inflammation signal to the development and progression of CRC. The gene discussed is IL6; the disease is colorectal carcinoma.