TGFB1 and colorectal carcinoma: In terms of CRC, our previous studies showed that over-expression of CEMIP predicted poor outcomes of CRC patients and was positively correlated with CRC metastasis [15–17], and CEMIP facilitated the infiltration of immunosuppressive neutrophils and drove immune suppression via the TGFβ-CXCL3/1-CXCR2 axis in liver metastasis [18].