However, we found that CRC patients with high-CEMIP + low-GRAF1, high-CEMIP + high-GRAF1, had worse PFS and OS than patients with low-CEMIP + high-GRAF1, low-CEMIP + low-GRAF1 respectively (Fig. 1A, B), suggesting that the combination of CEMIP and GRAF1 could effectively predict the survival of patients. The gene discussed is CEMIP; the disease is colorectal carcinoma.