Considering we had proved that CEMIP activated CDC42/MAPK pathway, and it was reported that MAPK signaling was a key regulator of epithelial-mesenchymal transition (EMT) and tumor metastasis, we deduced that CEMIP promoted CRC metastasis via MAPK signaling-induced EMT [30, 31]. The gene discussed is CEMIP; the disease is colorectal carcinoma.