For example, MSC-derived exosomes can significantly increase the expression of MVB1 RNA and C-X-C motif chemokine ligand (CXCL) 8, which decreases the quantity of immunoglobulin M (IgM) in B lymphocytes.212 It should be noted that MSCs can also secrete IL-6 to promote the M2-like polarization of TAMs.213,214 Additionally, some cytokines, including IL10, hepatocyte growth factor (HGF), leukemia inhibitory factor (LIF), CXCL2, CXCL20, and VEGF-C, also play a significant role in the increased accumulation of MSC-EVs at tumor sites and inflammation suppression.215. This evidence concerns the gene HGF and neoplasm.