In this nanoplatform, poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA) is employed to target mitochondria, and modified dichloroacetate (DCA) is employed to suppress pyruvate dehydrogenase kinase 1 (PDHK1) to induce mitochondrial oxidative stress, which can lead to pyroptosis and further mediate ICD in osteosarcoma cell lines.405 However, OPDEA-PDCA can also promote the release of soluble PD-L1. The gene discussed is PDK1; the disease is osteosarcoma.