CCR7 and osteosarcoma: Agonists of GMR-4 or antibodies against IL-23 may be potential options for osteosarcoma immunotherapy.54,55 Additionally, DCs may also play a significant role in the pulmonary metastasis of advanced osteosarcoma.56 A comprehensive study showed that CCR7 contributed to the proliferation, deformation, and migration of DCs, thereby playing an important role in pulmonary metastasis of osteosarcoma.