IL-8 released from self-seeded CTCs can effectively induce osteosarcoma cell proliferation and pulmonary metastasis in ex vivo assays.220 Consequently, suppressing the activity and secretion of IL-8 might be a potential antitumor strategy that can possibly be used in combination with various agonists or antagonists of other cytokines. Here, CXCL8 is linked to osteosarcoma.