Besides, activated mTORC2 (mTOR complex 2) can also promote the hyperactivation of Akt by phosphorylating Akt.48 Two tumor suppressors [phosphatase and tensin homolog (PTEN)49 and inositol polyphosphate 4-phosphatase type II (INPP4B)]50 prevent the activation of downstream of PI3K by dephosphorylating PIP3 and PIP2.51,52. The gene discussed is PTEN; the disease is neoplasm.