Cell apoptosis was further analyzed by flow cytometry, and the results showed that fewer RTECs overexpressing ENTPD5 underwent apoptosis, and a higher number of ENTPD5-knockdown cells underwent apoptosis (Fig. 3F–I), suggesting that ENTPD5 participates in apoptosis in DKD. The gene discussed is ENTPD5; the disease is diabetic kidney disease.