Among HLA-B alleles, HLA-B*35:01 (5.3% vs. 1.7%, OR = 3.428, 95% CI  = 1.213-9.690, p = 0.033) and B*55:02 (7.0% vs. 2.9%, OR = 2.506, 95% CI = 1.036-6.066, p = 0.046) were overrepresented in mild COVID-19 patients compared with controls, whereas HLA-B*51:01 was more prevalent in severe cases than controls (9.4% vs. 4.1%, OR = 2.631, 95% CI  = 0.901-7.685, p = 0.040). Here, HLA-B is linked to COVID-19.