The dorsal hippocampus is therefore of special interest in Cnih3 mutant mice because of the association of CNIH3 to addiction phenotypes and schizophrenia in humans (Drummond et al., 2012; Nelson et al., 2016) and reported mouse knock-out interactions with sex and estrous affecting hippocampal learning phenotypes and glutamatergic signaling pathways (H.E. Frye et al., 2021). The gene discussed is CNIH3; the disease is schizophrenia.