Because c-Myb, another member of the MYB family of transcription factors, is known to suppress 5-LO expression in undifferentiated HL-60 cells and in human macrophages during phagocytosis of tumor cells (Ponton et al, 1997; Ringleb et al, 2018), we further pursued the role of E2Fs and b-Myb in suppression of 5-LO in HCT-116 and HT-29 cells. The gene discussed is MYBL2; the disease is neoplasm.