As b-Myb and c-Myb share their DNA consensus element (Oh & Reddy, 1999), it is not surprising that the MYB binding elements responsible for the b-Myb–mediated suppression of 5-LO in the tumor cells are identical to the elements involved in c-Myb–mediated suppression of the enzyme in undifferentiated monocytic cells. The gene discussed is MYB; the disease is neoplasm.