Furthermore, 5-LO products are known to activate anti-apoptotic signaling pathways and promote tumor cell proliferation in vitro and metastasis and angiogenesis in vivo (Boado et al, 1992; Hong et al, 1999; Avis et al, 2001; Romano et al, 2001; Chen et al, 2006). Here, ALOX5 is linked to neoplasm.