We provide additional confirmation of the phenotype association of two such variants, skeletal dysplasia 2 (SD2; also known as mild disproportionate dwarfism; OMIA variant ID 78; OMIA 001772–9615;) and ITGA10 gene-related disproportionate short-limbed chondrodysplasia (OMIA variant ID 336; OMIA 001886–9615) [30, 37], on mixed breed ancestry backgrounds. The gene discussed is ITGA10; the disease is Severe short stature.