This includes the IGFBP5 gene candidate variant for bald thigh syndrome in sighthounds [22], SLC7A9 and SLC3A1 gene variants associated with cystinuria in Bulldogs [23, 24], as well as PDK4 and TTN gene risk variants for dilated cardiomyopathy (DCM) in Dobermans [25–27]. The gene discussed is IGFBP5; the disease is dilated cardiomyopathy.