To determine whether a CNV in an intron near the 3’ end of the Nrxn1 gene elicits behavioral phenotypes, we also generated a mouse model carrying a ~20 kb deletion at intron 17 of Nrxn1α (Nrxn1ΔIntron17/+or Nrxn1ΔIntron17/ΔIntron17; subsequently referred to as ΔIntron17/+ or ΔIntron17/ΔIntron17) that is similar to a CNV identified in an individual on the autism spectrum (in the Autism Spectrum Program of Excellence (ASPE) cohort [27]). The gene discussed is NRXN1; the disease is autism.