By analyzing the TCGA database data through the UALCAN website, we found that CST1 expression was significantly upregulated in esophageal cancer tissues compared with normal tissues (Fig 1A–1D), and closely correlated with grades (Fig 1B), stages (Fig 1C), and lymph node metastases (Fig 1D) of cancerous tissues. The gene discussed is CST1; the disease is esophageal cancer.