TLR2 and clostridium difficile infection: The role of eosinophils remains unclear in CDI, however Cowardin et al., showed hypervirulent strains expressing the binary toxin (CDT) was able to suppress host eosinophil response through activation of the Toll-like Receptor 2 (TLR2)-dependent pathway; subsequent adoptive transfer of TLR2-deficient eosinophils was able to restore survival rates of TLR2-/- mice [247].