The three proteins eIF5A1, DHPS, and DOHH are highly conserved in eukaryotes and their pathogenic variants are collectively referred to as eIF5A1 and hypusination-related disorders that are characterized by global developmental delay, intellectual disability, facial dysmorphism, and microcephaly (Ziegler et al., 2022). This evidence concerns the gene EIF5A and microcephaly.