It has been proposed that STAT3 plays an important role in the suppression of hepatic injury during cholestasis.45 In the present study, treatment with an FXR agonist led to increased FXR binding to the Stat3 promoter in PNAC mouse liver, inducing STAT3 phosphorylation associated with enhanced expression of FXR target genes. Here, NR1H4 is linked to cholestasis.