This scenario suggests that children with LTBI, characterized by a simultaneous strong IFN-γ responses to QFT (regardless of tube) and HBHA-based IGRA, may be distinguished from patients with active TB, subclinical TB or incipient TB, that start losing the ability to respond to HBHA while maintaining a strong response against RD1 antigens. Here, PDE6B is linked to tuberculosis.