SNCA and multiple system atrophy: This type resembled most closely one of the filaments from in vitro seeded aggregation of wild-type recombinant α-synuclein with seeds of MSA filaments (PDB 7NCG) [20] The same protofilament fold was first observed for filaments assembled from recombinant E46K α-synuclein (PDB:6UFR) [2].