MAPT and supranuclear palsy, progressive, 1: However, despite the common Tau neuropathology, numerous studies have shown that Tau is processed distinctly in each of these conditions, which is reflected in differences in inclusion morphology, biochemical profile, and ultrastructure among the Tauopathies including PSP (Arakhamia et al., 2020; Falcon et al., 2019; Falcon, Zhang, Murzin, et al., 2018; Falcon, Zhang, Schweighauser, et al., 2018; Shi et al., 2021; Taniguchi‐Watanabe et al., 2016).