IGHE and allergic disease: For all these reasons, the use of sample pretreatment systems based on the removal of IgG from serum prior to its analysis by in vitro diagnostic allergy tests has been proposed.[8, 9] To carry out this removal, commercial capture systems based on particles or columns that have conjugated a protein with selective binding capacity to the constant region of human IgG (and without IgE binding capacity) have been used.