Additionally, the popularization of multiplex allergy diagnostic methods (simultaneous detection of immunoglobulins against multiple allergens) worsens this situation, since false positives have been described due to the incorrect detection of allergen‐specific IgG (of unknown clinical utility) as if it were allergen‐specific IgE (which is the validated biomarker for diagnosis of allergic diseases).[6, 7]. This evidence concerns the gene IGHE and allergic disease.