Knockdown of FOXL2 in NSCLC significantly decreased TGF‐β receptor I, TGF‐β receptor II, Snail, p‐Smad3, N‐cadherin, MMP2, MMP9, and Vimentin levels and markedly increased E‐cadherin expression, and the metastatic ability of NSCLC cells was reduced. This evidence concerns the gene CDH1 and non-small cell lung carcinoma.