For example, intake of probiotics can alter both social and anxiety-like behaviors as well as brain neurochemical systems, such as oxytocin (OT) and corticotropin releasing factor (CRF), in several animal models (O'Sullivan et al., 2011; Buffington et al., 2016; Liu et al., 2016; Wang et al., 2016). The gene discussed is CRH; the disease is Anxiety.