The EBV infection in NPC is typically represented by a type II latency pattern, in which Epstein–Barr nuclear antigen 1 (EBNA1), latent membrane protein (LMP)1 and 2, and non-coding RNAs are expressed and induce further genetic and epigenetic changes, contributing to the acquisition of several cancer hallmarks. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.