LMP1-targeted DNAzymes contribute to the inhibition of LMP1-induced radio-resistance in NPC by repressing the LMP1/JNKs/HIF-1/VEGF-mediated angiogenesis and inhibiting the LMP1/Akt-induced telomerase activity (Ma et al., 2013; Yang et al., 2014, 2015). Here, HIF1A is linked to nasopharyngeal carcinoma.